Amyloid-β protein and oxidative stress in Alzheimer’s disease

doi:10. 3969 / j.issn.1671-7856. 2021. 10. 020

Home > Archive>Volume 31, Issue 10, 2021 >131-135. DOI:10. 3969 / j.issn.1671-7856. 2021. 10. 020

Amyloid-β protein and oxidative stress in Alzheimer’s disease
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                        10. 3969 / j.issn.1671-7856. 2021. 10. 020
                    
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                        SHAO Simai1SHAO Simai
School of Basic Medical Science, Henan University of Chinese Medicine, Zhengzhou 450046, China
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SHI Ming1SHI Ming
School of Basic Medical Science, Henan University of Chinese Medicine, Zhengzhou 450046, China
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YU Ziyang1YU Ziyang
School of Basic Medical Science, Henan University of Chinese Medicine, Zhengzhou 450046, China
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YUAN Ye2YUAN Ye
College of Traditional Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou 450046
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YOU Yanwen1YOU Yanwen
School of Basic Medical Science, Henan University of Chinese Medicine, Zhengzhou 450046, China
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HAO Li1HAO Li
School of Basic Medical Science, Henan University of Chinese Medicine, Zhengzhou 450046, China
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ZHANG Zijuan1ZHANG Zijuan
School of Basic Medical Science, Henan University of Chinese Medicine, Zhengzhou 450046, China
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ZHANG Zhenqiang2ZHANG Zhenqiang
College of Traditional Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou 450046
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Affiliation:1.School of Basic Medical Science, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. College of Traditional Chinese Medicine, Henan University of Chinese Medicine, Zhengzhou 450046
Clc Number:R-33
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Abstract:

Oxidative stress is an major factor that affects aging and neurological diseases, which plays an crucial role in the development and progression of multiple neurodegenerative diseases. Amyloid-beta protein ( Aβ) is a major component of senile plaques, and its aggregation and abnormal deposition are major contributors to the pathogenesis of Alzheimer’s disease (AD). Studies have shown that oxidative stress triggered by Aβ deposition induces neuronal loss, cell death in cognitive memory-related brain regions, and finally causes the occurrence and development of AD pathology. This article focuses on the mechanism of toxic production of amyloid peptide in the occurrence and development of AD, the oxidation process of macromolecules and the process of the interaction between amyloid peptide and oxidative stress to clarify the relationship between amyloid peptide and oxidative stress in the occurrence and development of AD. This review provides strong theoretical support and research directions to promote studies on antioxidants in AD.

Key words:Alzheimer’s disease; Amyloid peptide; Oxidative stress

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Received:December 07,2020
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Online: November 29,2021
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