In recent years, the incidence of premature ovarian failure (POF) has been increasing. Because of its complex etiology and difficult treatment, POF has attracted wide attention from scholars at home and overseas. To study the occurrence and development of POF, and to find better treatment options, it is essential to construct a reliable animal model of POF. This review will discuss and analyze the method used to construct POF mouse models by domestic and foreign investigators in the past five years. Furthermore, we will compare the advantages, disadvantages and clinical relevance of various modeling method , which aim to provide new insights into the basic scientific understanding and clinical diagnosis and treatment of POF.