Coagulation dysfunction in coronavirus disease 2019 and blood stasis symptom of traditional Chinese medicine

doi:10. 3969 / j.issn.1671-7856. 2022. 01. 012

Home > Archive>Volume 32, Issue 1, 2022 >89-96. DOI:10. 3969 / j.issn.1671-7856. 2022. 01. 012

Coagulation dysfunction in coronavirus disease 2019 and blood stasis symptom of traditional Chinese medicine
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                        10. 3969 / j.issn.1671-7856. 2022. 01. 012
                    
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Author:
                        ZHOU LiZHOU Li
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS), Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, National Health Commission of the People’s Republic of China, Key Laboratory of Human Disease Animal Models, State Administration of Traditional Chinese Medicine, Beijing 100021, China
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QIN ChuanQIN Chuan
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS), Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, National Health Commission of the People’s Republic of China, Key Laboratory of Human Disease Animal Models, State Administration of Traditional Chinese Medicine, Beijing 100021, China
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Affiliation:Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS), Comparative Medicine Center, Peking Union Medical College (PUMC), Key Laboratory of Human Disease Comparative Medicine, National Health Commission of the People’s Republic of China, Key Laboratory of Human Disease Animal Models, State Administration of Traditional Chinese Medicine, Beijing 100021, China
Clc Number:R-33
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Abstract:

Coronavirus disease 2019 (COVID-19) is an acute respiratory infectious disease caused by infection with the novel coronavirus SARS-CoV-2,which has spread worldwide. Although pneumonia is the primary symptom of COVID-19, nearly 20% of patients and almost all severe and critical patients have an abnormal coagulation function. Coagulation dysfunction and thrombosis have emerged as major causes of death in COVID-19 patients. A detailed understanding of the relationship between COVID-19 and coagulation dysfunction deserves urgent exploration for clinical treatment and basic research. In this article, the mechanism of coagulation dysfunction in COVID-19 were reviewed on the basis of molecular mechanistic pathways and the theory of blood stasis in traditional Chinese medicine to provide scientific evidence for the application of traditional Chinese medicine and a reference for future studies of COVID-19-associated coagulopathy.

Key words:COVID-19; SARS-CoV-2; Coagulation dysfunction; thrombosis; blood stasis

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Received:December 06,2021
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Online: March 15,2022
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