Research progress of traditional Chinese medicine on the basis of animal models of chemically-induced inflammatory bowel disease

doi:10. 3969 / j.issn.1671-7856. 2022. 01. 017

Home > Archive>Volume 32, Issue 1, 2022 >127-131. DOI:10. 3969 / j.issn.1671-7856. 2022. 01. 017

Research progress of traditional Chinese medicine on the basis of animal models of chemically-induced inflammatory bowel disease
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                        10. 3969 / j.issn.1671-7856. 2022. 01. 017
                    
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                        CAO Yuling1CAO Yuling
Hunan Key Laboratory for Quality Evaluation of Bulk Medicinal Materials Produced in Hunan, Hunan University of Traditional Chinese Medicine, Changsha 410208, China
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SONG Houpan1SONG Houpan
Hunan Key Laboratory for Quality Evaluation of Bulk Medicinal Materials Produced in Hunan, Hunan University of Traditional Chinese Medicine, Changsha 410208, China
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ZENG Jianguo2ZENG Jianguo
Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan Agricultural University, Changsha 410128
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LIAO Duanfang1LIAO Duanfang
Hunan Key Laboratory for Quality Evaluation of Bulk Medicinal Materials Produced in Hunan, Hunan University of Traditional Chinese Medicine, Changsha 410208, China
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Affiliation:1.Hunan Key Laboratory for Quality Evaluation of Bulk Medicinal Materials Produced in Hunan, Hunan University of Traditional Chinese Medicine, Changsha 410208, China. 2. Hunan Key Laboratory of Traditional Chinese Veterinary Medicine, Hunan Agricultural University, Changsha 410128
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Abstract:

Inflammatory bowel disease (IBD) is the result of a combination of genetic, environmental and immune factors. Although the disease is classified as a refractory disease in modern medicine, it has significant advantages in treating IBD on the basis of traditional Chinese medicine syndrome differentiation. Therefore, it is very important to explore appropriate animal models to study the effects and mechanisms of traditional Chinese medicine in the treatment of IBD. The chemically induced IBD model is the most commonly used to study the pathogenesis of IBD. This article summarizes the recent research progress of this type of model in Chinese medicine and discusses the characteristics of the model, pathological mechanism, research ideas and applications to facilitate the design of basic research of IBD.

Key words:traditional Chinese medicine;inflammatory bowel disease; chemically-induced; animal model

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Received:November 10,2021
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Online: March 15,2022
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