Research progress on establishment of animal model of IgA nephropathy by heterogeneous protein induction

doi:10. 3969 / j.issn.1671-7856. 2022. 12. 011

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Research progress on establishment of animal model of IgA nephropathy by heterogeneous protein induction
DOI:
                        10. 3969 / j.issn.1671-7856. 2022. 12. 011
                    
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Author:
                        YANG Wen2,3,1YANG Wen
1. College of Pediatrics, Medicine Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China.
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Affiliation:1. College of Pediatrics, Medicine Henan University of Traditional Chinese Medicine, Zhengzhou 450046, China. 2. Medicine Henan University of Traditional Chinese Medicine, Zhengzhou 450046. 3. Department of Pediatrics, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450003
Clc Number:R-33
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Abstract:

This paper summarizes various Methods for establishing animal models of IgA nephropathy (IgAN) by immune induction. The models’ respective characteristics and shortcomings and the similarities and differences between them are discussed. We propose that improvements to models are needed and provide ideas for establishing safer, more stable animal models with a higher success rate and robust repeatability that more closely mimic human IgAN.

Key words:IgAN; animal model; immune induction; research progress

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Received:March 29,2022
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Online: August 02,2023
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