Research progress on the ubiquitin ligase TRIM46: a review based on the TRIM family

doi:10. 3969 / j.issn.1671-7856. 2022. 02. 015

Home > Archive>Volume 32, Issue 2, 2022 >99-104. DOI:10. 3969 / j.issn.1671-7856. 2022. 02. 015

Research progress on the ubiquitin ligase TRIM46: a review based on the TRIM family
DOI:
                        10. 3969 / j.issn.1671-7856. 2022. 02. 015
                    
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Author:
                        SHENG Hanxuan1SHENG Hanxuan
Key Laboratory of Human Disease Comparative Medicine, National Health Commission of China (NHC), Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Peking Union Medical College & Comparative Medical Center, Beijing 100021, China.
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ZHANG LianfengZHANG Lianfeng
2. Beijing Engineering Research Center for Experimental Animal Models of Human Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Peking Union Medical College & Comparative Medical Center, Beijing 100021. 3. Neuroscience Center, Chinese Academy of Medical Sciences, Beijing 100730
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ZHANG Li1ZHANG Li
Key Laboratory of Human Disease Comparative Medicine, National Health Commission of China (NHC), Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Peking Union Medical College & Comparative Medical Center, Beijing 100021, China.
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Affiliation:1. Key Laboratory of Human Disease Comparative Medicine, National Health Commission of China (NHC), Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Peking Union Medical College & Comparative Medical Center, Beijing 100021, China. 2. Beijing Engineering Research Center for Experimental Animal Models of Human Diseases, Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Peking Union Medical College & Comparative Medical Center, Beijing 100021. 3. Neuroscience Center, Chinese Academy of Medical Sciences, Beijing 100730
Clc Number:R-33
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Abstract:

TRIM46, a relatively novel tripartite motif (TRIM) family protein, consists of two RING fingers, a B- box motif, a coiled-coil region, C-terminal COS, FN3 and B30. 2 / SPRY domains. TRIM46 controls neuronal polarity and axon specification by driving the formation of parallel microtubule arrays. TRIM46 plays a role in tumor proliferation and migration and is also involved in innate immune regulation. The data from Genecards suggested that TRIM46 was highly expressed in the brain, although it was broadly expressed in other human organs. This review focuses on recent studies of TRIM46 protein structure and function. Future research directions and method for gene-edited animals regarding TRIM46 are also predicted and discussed.

Key words:TRIM family; TRIM46; neuronal polarity; function; expression; innate immunity

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Received:March 19,2021
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Online: April 12,2022
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