Advances in the research on immunosenescence that affects cellular immunity of periodontitis

doi:10. 3969 / j.issn.1671-7856. 2022. 02. 018

Home > Archive>Volume 32, Issue 2, 2022 >116-125. DOI:10. 3969 / j.issn.1671-7856. 2022. 02. 018

Advances in the research on immunosenescence that affects cellular immunity of periodontitis
DOI:
                        10. 3969 / j.issn.1671-7856. 2022. 02. 018
                    
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Author:
                        YAO Yanzi1YAO Yanzi
School of Stomatology, Zunyi Medical University, Zunyi 563000, China
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HU HuanHU Huan
2. Special Key Laboratory of Oral Diseases Research, Higher Education Institution in Guizhou Province, Zunyi Key Laboratory of Oral Diseases Research, Zunyi 563000. 3. Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution, Zunyi 563000.
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WANG Qian2WANG Qian
Special Key Laboratory of Oral Diseases Research, Higher Education Institution in Guizhou Province, Zunyi Key Laboratory of Oral Diseases Research, Zunyi 563000
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LIU Jianguo2LIU Jianguo
Special Key Laboratory of Oral Diseases Research, Higher Education Institution in Guizhou Province, Zunyi Key Laboratory of Oral Diseases Research, Zunyi 563000
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ZHOU XuedongZHOU Xuedong
1. School of Stomatology, Zunyi Medical University, Zunyi 563000, China.4. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041
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Affiliation:1. School of Stomatology, Zunyi Medical University, Zunyi 563000, China. 2. Special Key Laboratory of Oral Diseases Research, Higher Education Institution in Guizhou Province, Zunyi Key Laboratory of Oral Diseases Research, Zunyi 563000. 3. Microbial Resources and Drug Development Key Laboratory of Guizhou Tertiary Institution, Zunyi 563000. 4. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041
Clc Number:R-33
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Abstract:

Currently, many countries have rapidly stepped into the aging society and the elderly population is growing sharply. The aging process is accompanied by a series of changes in the immune system, which is known as “immunosenescence” and leads to an increase in the incidence of various infections and mortality from geriatric diseases, increasing the demand for healthcare in all counties. Periodontitis is chronic inflammation of periodontal tissue caused by an interaction between pathogenic bacteria and host immune system, which has shown a rising trend in vulnerability and periodontal destruction in the elderly population. It seriously affects both physical and mental health of the elderly and increases the medical burden. This article reviews the effects of senescence and immunosenescence on periodontitis, especially the effects of aging on immune cells, which include innate immune cells and adaptive immune cells, on periodontitis.

Key words:periodontitis; immunosenescence; immune cells

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Received:December 02,2020
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Online: April 12,2022
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