Progress on mitochondrial injury in skeletal muscle induced by chronic obstructive pulmonary disease and treatment with traditional Chinese medicine

doi:10. 3969 / j.issn.1671-7856. 2022. 02. 020

Home > Archive>Volume 32, Issue 2, 2022 >133-137,144. DOI:10. 3969 / j.issn.1671-7856. 2022. 02. 020

Progress on mitochondrial injury in skeletal muscle induced by chronic obstructive pulmonary disease and treatment with traditional Chinese medicine
DOI:
                        10. 3969 / j.issn.1671-7856. 2022. 02. 020
                    
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Author:
                        ZHAO GaoyuanZHAO Gaoyuan
1.Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Co-constructed by Henan Province & Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Zhengzhou 450046.
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MIAO YufangMIAO Yufang
1.Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Co-constructed by Henan Province & Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Zhengzhou 450046.
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HOU RunsuHOU Runsu
1.Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Co-constructed by Henan Province & Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Zhengzhou 450046.
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LI KangchenLI Kangchen
1.Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Co-constructed by Henan Province & Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Zhengzhou 450046.
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TIAN YangeTIAN Yange
1.Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Co-constructed by Henan Province & Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Zhengzhou 450046. 3. Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046
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Affiliation:1.Collaborative Innovation Center for Chinese Medicine and Respiratory Disease Co-constructed by Henan Province & Education Ministry of P.R. China, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Zhengzhou 450046. 3. Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046
Clc Number:R-33
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Abstract:

Skeletal muscle dysfunction (SMD) is a common complication of chronic obstructive pulmonary disease (COPD), which usually causes a decline in exercise activity and quality of life. Mitochondrial injury is one of the main mechanisms by which SMD coexists with COPD, and injury is mainly caused by oxidative stress, energy metabolism disorders, and abnormal autophagy. An increase in mitochondrial reactive oxygen species production leads to oxidative stress and decreased mitochondrial biosynthesis, volume density, and mitochondrial respiratory function (respiratory control ratio evaluation). Decreased mitochondrial membrane potential and ATP synthase activity and excessive opening of the mitochondrial membrane permeability transition pore may result in mitochondrial-mediated metabolic disorders. Severe oxidative stress and systemic inflammation can trigger abnormal mitochondrial autophagy and accelerate degradation and clearance of mitochondria. Traditional Chinese medicine ( TCM) has obvious benefits in improving exercise ability and quality of life in patients with COPD. With the in-depth study of TCM in recent years, TCM has been shown to improve mitochondrial injury after treatment of COPD-induced SMD. In this study, we reviewed the relevant literature and summarized the relationship between mitochondrial injury and COPD combined with SMD and treatment with TCM. This review may provide a basis for further research.

Key words:chronic obstructive pulmonary disease; skeletal muscle dysfunction; mitochondrial injury; traditional Chinese medicine

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Received:January 14,2021
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Online: April 12,2022
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