Effect of icariin the apoptosis and inflammation of RAW264. 7 cells induced by ox-LDL

doi:10. 3969 / j.issn.1671-7856. 2022. 03. 002

Home > Archive>Volume 32, Issue 3, 2022 >9-15. DOI:10. 3969 / j.issn.1671-7856. 2022. 03. 002

Effect of icariin the apoptosis and inflammation of RAW264. 7 cells induced by ox-LDL
DOI:
                        10. 3969 / j.issn.1671-7856. 2022. 03. 002
                    
CSTR:
                        [cstr]
                    
Author:
                        LI Tengteng1LI Tengteng
Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun 130021, China
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
XU Dongsheng2XU Dongsheng
Department of Oncology, the First Hospital of Jilin University, Changchun 130000
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
LI Qi1LI Qi
Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun 130021, China
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
WU Di1WU Di
Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun 130021, China
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
ZHANG Yang1ZHANG Yang
Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun 130021, China
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
REN Liqun1REN Liqun
Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun 130021, China
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
LI Xiangjun1LI Xiangjun
Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun 130021, China
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site

                    
Affiliation:1.Department of Experimental Pharmacology and Toxicology, School of Pharmacy, Jilin University, Changchun 130021, China. 2. Department of Oncology, the First Hospital of Jilin University, Changchun 130000
Clc Number:R-33
Fund Project:

Article

Figures

Metrics

Reference

Cited by

Materials

Comments

Abstract:

Objective To study the effect of icariin ( ICA) on apoptosis and inflammation of leukemic mouse macrophages (RAW264. 7) induced by oxidized low-density lipoprotein (ox-LDL), and to clarify the anti-arterial effect of ICA and the role of atherosclerosis (AS). Methods RAW264. 7 cells were treated with ox-LDL to induce foam cell models. The effects of low, medium, and high doses of ICA on RAW264. 7 cell viability, apoptosis, foaming and secretion of inflammatory factors IL-1β, IL-6 and TNF-α were investigated. Western blot was used to assess the effect of ICA on protein expression of Bcl-2, Bax, Caspase-3, IκBα and NF-κB p65. Results ICA improved cell viability and reduced apoptosis, the formation of foamy macrophages, secretion of inflammatory factors IL-1β, IL-6, TNF-α, Bcl-2, Caspase-3 and NF-κB p65 protein expression, and up-regulated protein expression of Bax and IκBα. Conclusions ICA reduces apoptosis of foamy macrophages and inhibits the expression of inflammatory factors, thereby delaying the development of atherosclerosis.

Key words:icariin; macrophages; atherosclerosis; apoptosis; inflammation

Get Citation

Copy

Article Metrics

Abstract:2122
PDF: 3026
HTML: 0
Cited by: 0

History

Received:January 22,2021
Revised:
Adopted:
Online: April 18,2022
Published:

Home

About this journal

Editorial Board

Info for Author

Contact Us

中文版

Get Citation

Share

Article Metrics

History

Article QR Code