Research progress on the regulation of non-coding RNA in glucose metabolism re-editing in oral squamous cell carcinoma

doi:10. 3969 / j.issn.1671-7856. 2022. 03. 013

Home > Archive>Volume 32, Issue 3, 2022 >91-97. DOI:10. 3969 / j.issn.1671-7856. 2022. 03. 013

Research progress on the regulation of non-coding RNA in glucose metabolism re-editing in oral squamous cell carcinoma
DOI:
                        10. 3969 / j.issn.1671-7856. 2022. 03. 013
                    
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Author:
                        YANG YiyanYANG Yiyan
Laboratory Animal Center, Shanxi Medical University,Shanxi Key Laboratory of Experimental Animal Science and Human Disease Animal Model, Taiyuan 030001, China
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GAO JipingGAO Jiping
Laboratory Animal Center, Shanxi Medical University,Shanxi Key Laboratory of Experimental Animal Science and Human Disease Animal Model, Taiyuan 030001, China
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XU GuoqiangXU Guoqiang
Laboratory Animal Center, Shanxi Medical University,Shanxi Key Laboratory of Experimental Animal Science and Human Disease Animal Model, Taiyuan 030001, China
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WANG XiaotangWANG Xiaotang
Laboratory Animal Center, Shanxi Medical University,Shanxi Key Laboratory of Experimental Animal Science and Human Disease Animal Model, Taiyuan 030001, China
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SONG GuohuaSONG Guohua
Laboratory Animal Center, Shanxi Medical University,Shanxi Key Laboratory of Experimental Animal Science and Human Disease Animal Model, Taiyuan 030001, China
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Affiliation:Laboratory Animal Center, Shanxi Medical University,Shanxi Key Laboratory of Experimental Animal Science and Human Disease Animal Model, Taiyuan 030001, China
Clc Number:R-33
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Abstract:

Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors of the head and neck, and its incidence is increasing yearly. Glucose metabolism reprogramming is the most representative metabolic feature of tumors, which has unique characteristics of energy metabolism. In the case of sufficient oxygen, tumor cells prefer glycolysis over highly productive mitochondrial oxidative phosphorylation. Current studies have shown that non-coding RNA (ncRNA) directly targets glucose transport protein and key enzyme to change glucose metabolism or indirectly changes glucose metabolism by regulating cancer-related signaling pathways during the occurrence and development of OSCC. This article reviews the mechanism of ncRNA in the regulation of aerobic glycolysis in OSCC.

Key words:non-coding RNA; oral squamous cell carcinoma; glucose metabolism; aerobic glycolysis

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Received:September 08,2021
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Online: April 18,2022
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