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Home > Archive>Volume 32, Issue 3, 2022 >112-116. DOI:10. 3969 / j.issn.1671-7856. 2022. 03. 016
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Research progress on animal models of social defeat
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1. School of Pharmacy, Guizhou University of TCM, Guiyang 550025, China. 2. Hunan Center of Drug Safety Evaluation and Research of Drugs & Key Laboratory of New Drug Efficacy and Safety Evaluation of Hunan Province, Changsha 410331. 3. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193. 4. Hunan Drug Examination and Inspection Center, Changsha 410001

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R-33

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    Abstract:

    Social defeat stress is a social stress method based on the subordination relationship between species. It leads to depression-like and other behavioral changes through frustrating behaviors between individuals of the same animal or different strains. Currently, few studies examine anti-social defeat drugs and the existing animal models have certain shortcomings and there is no uniform standard. This article reviews recent research on the application of social defeat animal models and their pathogenesis and provides a reference animal model for the development of anti-social defeat drugs.

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History
  • Received:December 12,2020
  • Online: April 18,2022
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