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Home > Archive>Volume 32, Issue 3, 2022 >117-122. DOI:10. 3969 / j.issn.1671-7856. 2022. 03. 017
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Research progress on ion channels and their functions in neutrophils
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1.Institute of Cerebrovascular Diseases Research, Xuanwu Hospital of Capital Medical University, Beijing 100053, China. 2. Department one of encephalopathy, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078

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R-33

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    Abstract:

    As a major type of phagocyte, neutrophils are involved in many physiological and pathological processes that include inflammation, phagocytosis of pathogens, elimination of tumor cells, and removal of necrotic tissue debris, which are closely related to the ion channels in neutrophils. This review discusses various types of ion channels and their roles in neutrophils, which include voltage-gated proton channels, potassium channels, ATP-gated P2X1 channels and chloride channels. With a focus on the ionic conductance mediated by partial ion channels in neutrophils, the pathological processes of neutrophils mediated by each channel are summarized. Recent findings are discussed from a functional perspective to contribute to selecting therapeutic targets.

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History
  • Received:January 20,2021
  • Online: April 18,2022
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