Research progress of telomere-binding protein and telomerase in different species

doi:10. 3969 / j.issn.1671-7856. 2022. 03. 020

Home > Archive>Volume 32, Issue 3, 2022 >136-142. DOI:10. 3969 / j.issn.1671-7856. 2022. 03. 020

Research progress of telomere-binding protein and telomerase in different species
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                        10. 3969 / j.issn.1671-7856. 2022. 03. 020
                    
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                        SHI GuiyingSHI Guiying
Institute of Laboratory Key Laboratory of Human Disease Sciences, Chinese Academy of Medical Sciences(CAMS); Comparative Medicine Center, Peking Union Medical College(PUMC), Key Laboratory of Human Disease Comparative Medicine, National Health Commission of the People’s Republic of China; Key Laboratory of Human Disease Key Laboratory of Human Disease Models, State Administration of Traditional Chineses Medicine, Beijing 100021, China
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HUANG YiyingHUANG Yiying
Institute of Laboratory Key Laboratory of Human Disease Sciences, Chinese Academy of Medical Sciences(CAMS); Comparative Medicine Center, Peking Union Medical College(PUMC), Key Laboratory of Human Disease Comparative Medicine, National Health Commission of the People’s Republic of China; Key Laboratory of Human Disease Key Laboratory of Human Disease Models, State Administration of Traditional Chineses Medicine, Beijing 100021, China
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LEI XuepeiLEI Xuepei
Institute of Laboratory Key Laboratory of Human Disease Sciences, Chinese Academy of Medical Sciences(CAMS); Comparative Medicine Center, Peking Union Medical College(PUMC), Key Laboratory of Human Disease Comparative Medicine, National Health Commission of the People’s Republic of China; Key Laboratory of Human Disease Key Laboratory of Human Disease Models, State Administration of Traditional Chineses Medicine, Beijing 100021, China
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LI XinyueLI Xinyue
Institute of Laboratory Key Laboratory of Human Disease Sciences, Chinese Academy of Medical Sciences(CAMS); Comparative Medicine Center, Peking Union Medical College(PUMC), Key Laboratory of Human Disease Comparative Medicine, National Health Commission of the People’s Republic of China; Key Laboratory of Human Disease Key Laboratory of Human Disease Models, State Administration of Traditional Chineses Medicine, Beijing 100021, China
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BAI LinBAI Lin
Institute of Laboratory Key Laboratory of Human Disease Sciences, Chinese Academy of Medical Sciences(CAMS); Comparative Medicine Center, Peking Union Medical College(PUMC), Key Laboratory of Human Disease Comparative Medicine, National Health Commission of the People’s Republic of China; Key Laboratory of Human Disease Key Laboratory of Human Disease Models, State Administration of Traditional Chineses Medicine, Beijing 100021, China
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Affiliation:Institute of Laboratory Key Laboratory of Human Disease Sciences, Chinese Academy of Medical Sciences(CAMS); Comparative Medicine Center, Peking Union Medical College(PUMC), Key Laboratory of Human Disease Comparative Medicine, National Health Commission of the People’s Republic of China; Key Laboratory of Human Disease Key Laboratory of Human Disease Models, State Administration of Traditional Chineses Medicine, Beijing 100021, China
Clc Number:R-33
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Abstract:

Telomeres are at the ends of eukaryotes chromosomes, protect chromosomes integrity in replication. Telomeres shorten with mitosis, telomerase prolong telomeres in cells, such as embryonic stem cell. There are two protein complexes binding on telomeres: shelterin complex and CST complex. Telomerase synthesize telomeres use its RNA components. Both the telomere binding proteins and the telomerase play great role in maintaining telomere length and stability. Although telomere sequences are similar in different species, telomere and telomerase functions are not related in physiological and/ or pathological conditions. Here we review the composition and function of telomere binding protein and telomerase, to understand the biological function of telomere and provide scientific basis for the treatment of telomere dysfunction.

Key words:telomere; shelterin; CST; telomerase

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Received:May 12,2021
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Online: April 18,2022
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