Trace amine-associated receptor 1 is a new regulating target of monoamine neurons in the central nervous system

doi:10. 3969 / j.issn.1671-7856. 2022. 04. 018

Home > Archive>Volume 32, Issue 4, 2022 >126-132. DOI:10. 3969 / j.issn.1671-7856. 2022. 04. 018

Trace amine-associated receptor 1 is a new regulating target of monoamine neurons in the central nervous system
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                        10. 3969 / j.issn.1671-7856. 2022. 04. 018
                    
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                        CAI Xiaowen1CAI Xiaowen
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China
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LAI Huiqin3LAI Huiqin
Department of Oncology, Zhongshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Zhongshan 528400
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LIANG Kaiyong1LIANG Kaiyong
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China
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HUANG YongHUANG Yong
1. School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. 2. Department of Acupuncture, Nanfang Hospital, Guangzhou 510515.
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Affiliation:1. School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China. 2. Department of Acupuncture, Nanfang Hospital, Guangzhou 510515. 3. Department of Oncology, Zhongshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Zhongshan 528400
Clc Number:R-33
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Abstract:

Trace amine-associated receptor 1 (TAAR1) is a new signal in neuropsychiatric research and plays an important physiological role in the central nervous system. Various reports have shown that the role of TAAR1 is closely related to trace amines and monoamine neurotransmitters. We discuss the research on TAAR1 in recent years from the aspects of TAAR1 expression, related ligands, mechanism pathway and the relationship with monoamine neurotransmitters. TAAR1 regulates dopaminergic, serotoninergic and glutamatergic neurons in the central nervous system and thus affects the levels of related substances inside and outside the cell. TAAR1 agonists also show great potential for promoting the cognitive function in pharmacological experiments. Targeting this receptor shows increasing advantages and potential for use in neuropsychiatric diseases.

Key words:trace amine-associated receptor 1; trace amines; monoamine neurotransmitter; central nervous system

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Received:June 10,2021
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Online: June 20,2022
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