PDCD2 promotes apoptosis of T cells and HIV latent-infected T cells induced by TRAIL

doi:10. 3969 / j.issn.1671-7856. 2022. 05. 001

Home > Archive>Volume 32, Issue 5, 2022 >1-6. DOI:10. 3969 / j.issn.1671-7856. 2022. 05. 001

PDCD2 promotes apoptosis of T cells and HIV latent-infected T cells induced by TRAIL
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                        10. 3969 / j.issn.1671-7856. 2022. 05. 001
                    
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Author:
                        YU WenhuiYU Wenhui
Comparative Medicine Center, Peking Union Medical College (PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Key Laboratory of Human Diseases Animal Models; State Administration of Traditional Chinese Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
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YANG ChenboYANG Chenbo
Comparative Medicine Center, Peking Union Medical College (PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Key Laboratory of Human Diseases Animal Models; State Administration of Traditional Chinese Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
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CONG ZheCONG Zhe
Comparative Medicine Center, Peking Union Medical College (PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Key Laboratory of Human Diseases Animal Models; State Administration of Traditional Chinese Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
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XUE JingXUE Jing
Comparative Medicine Center, Peking Union Medical College (PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Key Laboratory of Human Diseases Animal Models; State Administration of Traditional Chinese Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
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Affiliation:Comparative Medicine Center, Peking Union Medical College (PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Key Laboratory of Human Diseases Animal Models; State Administration of Traditional Chinese Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
Clc Number:R-33
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Abstract:

Objective To investigate apoptosis after PDCD2 overexpression in Jurkat and ACH2 cell lines. Methods Jurkat and ACH2 cell lines were used in this study. PDCD2 was stably expressed in the cell lines by lentivirus infection. Apoptosis was determined by flow cytometry after 24 hours of TRAIL treatment. Results Apoptosis was not significantly increased in Jurkat or ACH2 cells stably expressing PDCD2 compared with untransfected control cells. However, compared with the control group without PDCD2 overexpression, apoptosis was significantly higher in PDCD2- Jurkat and PDCD2-ACH2 cells induced by TRAIL (P< 0.05). Conclusions PDCD2 promotes apoptosis of T cell and HIV latent-infected T cells induced by TRAIL.

Key words:PDCD2; T cell; HIV latent infection; apoptosis

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Received:January 14,2022
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Online: July 05,2022
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