Effects of air pollution on male fertility and associated mechanisms

doi:10. 3969 / j.issn.1671-7856. 2022. 05. 017

Home > Archive>Volume 32, Issue 5, 2022 >115-120. DOI:10. 3969 / j.issn.1671-7856. 2022. 05. 017

Effects of air pollution on male fertility and associated mechanisms
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                        10. 3969 / j.issn.1671-7856. 2022. 05. 017
                    
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                        HU Jianying1HU Jianying
Institute for Immunization Program, Yunnan Center for Disease Control and Prevention, Kunming 650022, China
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DI Juan2DI Juan
Institute of Environment-related Health, Yunnan Center for Disease Control and Prevention, Kunming 650022
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CAO Yihui3CAO Yihui
Institute for Acute Infectious Diseases Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming, 650022
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ZHANG Ruixian4ZHANG Ruixian
Department of Disease Control and Prevention, the First People’s Hospital of Yunnan Provience, the Affiliated Hospital of Kunming University of Science and Technology, Kunming 650034
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Affiliation:1.Institute for Immunization Program, Yunnan Center for Disease Control and Prevention, Kunming 650022, China. 2. Institute of Environment-related Health, Yunnan Center for Disease Control and Prevention, Kunming 650022. 3. Institute for Acute Infectious Diseases Control and Prevention, Yunnan Center for Disease Control and Prevention, Kunming, 650022. 4. Department of Disease Control and Prevention, the First People’s Hospital of Yunnan Provience, the Affiliated Hospital of Kunming University of Science and Technology, Kunming 650034
Clc Number:R-33
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Abstract:

Air pollution affects not only sperm quality, such as the amount of sperm, sperm concentration, motility, progressive movement, morphology and other physical characteristics, but also the sperm genome, such as DNA fragmentation index and chromosome integrity. Air pollution has also been shown to influence male fertility by affecting the testosterone level or even testicular tissue cells. This review summarizes these issues on two levels: epidemiologically at the population level and from findings in animal research. This review also presents four possible mechanisms by which air pollutants affect spermatogenesis and development: as endocrine disruptors, by inducing reactive oxygen species, by destroying the blood-testosterone barrier, and by causing DNA mutations and epigenetic modifications. Finally, this review surveys recent studies suggesting medicines that have protective effects on sperm development.

Key words:air pollution; sperm quality; oxidative stress; epigenetic modification

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Received:June 02,2021
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Online: July 05,2022
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