Research progress on the mechanism of sarcolemma damage and repair treatment of Duchenne muscular dystrophy

doi:10. 3969 / j.issn.1671-7856. 2022. 06. 014

Home > Archive>Volume 32, Issue 6, 2022 >93-99. DOI:10. 3969 / j.issn.1671-7856. 2022. 06. 014

Research progress on the mechanism of sarcolemma damage and repair treatment of Duchenne muscular dystrophy
DOI:
                        10. 3969 / j.issn.1671-7856. 2022. 06. 014
                    
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Author:
                        ZHAO ZhipengZHAO Zhipeng
1.Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China. 2. State Key Laboratory of Primate Biomedical Research, Kunming 650500
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LI ShangangLI Shangang
1.Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China. 2. State Key Laboratory of Primate Biomedical Research, Kunming 650500
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Affiliation:1.Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China. 2. State Key Laboratory of Primate Biomedical Research, Kunming 650500
Clc Number:R-33
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Abstract:

Duchenne muscular dystrophy ( DMD) is a fatal muscle disease caused by the loss of dystrophin protein, which is localized in the sarcolemma. Currently, DMD research concentrates on how to treat the disease, and the restoration of membrane function has become a promising therapeutic approach. This review focuses on the mechanism by which muscle membrane damage is caused by dystrophin abnormality and summarizes the research progress regarding membrane repair therapy toward its clinical application.

Key words:Duchenne muscular dystrophy; sarcolemma damage; sarcolemma repair treatment

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Received:March 08,2022
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Online: August 01,2022
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