Research progress on the mechanism of PTEN in the repair of peripheral nerve injury

doi:10. 3969 / j.issn.1671-7856. 2022. 07. 017

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Research progress on the mechanism of PTEN in the repair of peripheral nerve injury
DOI:
                        10. 3969 / j.issn.1671-7856. 2022. 07. 017
                    
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                        CHU Yunfeng1CHU Yunfeng
Peking University Shenzhen Hospital, Shenzhen 518036, China
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YU Hongyan2YU Hongyan
Binchengqu Shili Hospital, Binzhou 256600
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YANG Qi1YANG Qi
Peking University Shenzhen Hospital, Shenzhen 518036, China
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PENG Yanbin1PENG Yanbin
Peking University Shenzhen Hospital, Shenzhen 518036, China
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CHEN Zhong1CHEN Zhong
Peking University Shenzhen Hospital, Shenzhen 518036, China
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YU FeiYU Fei
1. Peking University Shenzhen Hospital, Shenzhen 518036, China.3. National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Shenzhen 518036
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Affiliation:1. Peking University Shenzhen Hospital, Shenzhen 518036, China. 2. Binchengqu Shili Hospital, Binzhou 256600. 3. National & Local Joint Engineering Research Center of Orthopaedic Biomaterials, Shenzhen 518036
Clc Number:R-33
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Abstract:

Peripheral nerve injury is a major disease. Because the injury and repair mechanisms of the disease are unclear, its treatment is poor. Therefore, peripheral nerve injury has become a difficult point for orthopedics doctors. In recent years, phosphatase and tensin homologue deleted on chromosome 10 ( PTEN) has been widely studied to repair peripheral nerve injury. Here, we review the mechanism of PTEN in regulating synaptic regeneration, inflammatory and immune responses, neuronal apoptosis, neurotrophic related factors, and NF-κB, PI3K/ AKT/ mTOR and Jak / Stat signaling pathways during the repair of peripheral nerve injury to facilitate research.

Key words:peripheral nerve injury repair; PTEN; mechanism research

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Received:September 30,2021
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Online: November 09,2022
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