Precancerous lesions of gastric cancer (PLGC) are a key link between chronic atrophic gastritis and gastric cancer, and pre-gastric cancer intervention is significant for impacting gastric cancer. MNNG solution, in combination with a multi-factor modeling method , is a common method applied to the study of PLGC. However, at present, the prospects of MNNG solution use are still unclear, as the concentration and its factors are specific. This manuscript presents nearly five years’ worth of data from PLGC production in rats, summarizes four MNNG solution composite method with high usage rates, and discusses the model research progress in pre-stomach cancer rats in the context of MNNG solution concentration, administration, and multi-factor combination to guide the development of model method, animal experiments and further research on PLGC.