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Home > Archive>Volume 32, Issue 9, 2022 >97-108. DOI:10. 3969 / j.issn.1671-7856. 2022. 09. 014
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Relationship and Traditional Chinese Medicine intervention of pyroptosis and cardiovascular diseases
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1.Institute of Basic Medical Sciences of Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China.2. National Clinical Research Center for Chinese Medicine Cardiology, Beijing 100091. 3. Beijing Key Laboratory of Chinese Materia Pharmacology, Beijing 100091

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R-33

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    Abstract:

    Pyroptosis, a pro-inflammatory programmed mode of cell death that relies on caspases, is accompanied by the massive release of pro-inflammatory factors. There are two main signaling pathways in pyroptosis: the classical pathway mediated by Caspase-1 and non-classical pathway mediated by Caspases-4, 5 and 11. In addition, Caspase-3 and Caspase-8 can induce pyroptosis by cleaving Gasdermin E and Gasdermin D, respectively. Recent studies have shown that pyroptosis plays an important role in the occurrence and development of cardiovascular diseases. This article briefly summarizes the relationship between pyroptosis and cardiovascular diseases including atherosclerosis, myocardial ischemia /reperfusion, heart failure, hypertension, and diabetic cardiomyopathy. In addition, we review Traditional Chinese Medicine interventions explored in recent years to provide new ideas for the prevention and treatment of cardiovascular diseases that embrace the advantages of Traditional Chinese Medicine.

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History
  • Received:December 25,2021
  • Online: January 16,2023
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