There are many problems in the clinical treatment of depression, such as the high toxicity and side effects of drugs, and high relapse rate after medication withdrawal. Accordingly, there is an urgent need for the application of Traditional Chinese Medicine approaches. Likewise, increased basic research of Traditional Chinese Medicine is also needed. However, use of animal experiments for basic research creates some problems. In particular, animal models of depression based on modern medical etiology and pathology theory cannot be well applied to research of Traditional Chinese Medicines. Therefore, disease and syndrome models are often combined to construct a combination model of disease and syndrome suitable for animal experiments of Traditional Chinese Medicines. This article describes the preparation of a combination disease and syndrome model that uses correlative research as the starting point to make it more scientifically and reasonably applied to innovative research of Traditional Chinese Medicines.