Research progress on the regulatory mechanism of intestinal flora in the occurrence of depression

doi:10. 3969 / j.issn.1671-7856. 2022. 10. 017

Home > Archive>Volume 32, Issue 10, 2022 >130-135. DOI:10. 3969 / j.issn.1671-7856. 2022. 10. 017

Research progress on the regulatory mechanism of intestinal flora in the occurrence of depression
DOI:
                        10. 3969 / j.issn.1671-7856. 2022. 10. 017
                    
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                        CHEN WenluCHEN Wenlu
1. Laboratory Animal Center, Shanxi Key Laboratory of Experimental Animal Science and Animal Model of Human Disease,Shanxi Medical University, Taiyuan 030001, China.
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YAN XiaoruYAN Xiaoru
1. Laboratory Animal Center, Shanxi Key Laboratory of Experimental Animal Science and Animal Model of Human Disease,Shanxi Medical University, Taiyuan 030001, China.
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GAO JipingGAO Jiping
1. Laboratory Animal Center, Shanxi Key Laboratory of Experimental Animal Science and Animal Model of Human Disease,Shanxi Medical University, Taiyuan 030001, China.
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SONG GuohuaSONG Guohua
1. Laboratory Animal Center, Shanxi Key Laboratory of Experimental Animal Science and Animal Model of Human Disease,Shanxi Medical University, Taiyuan 030001, China. 2. School of Mental Health, Shanxi Medical University,Taiyuan 030001
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Affiliation:1. Laboratory Animal Center, Shanxi Key Laboratory of Experimental Animal Science and Animal Model of Human Disease,Shanxi Medical University, Taiyuan 030001, China. 2. School of Mental Health, Shanxi Medical University,Taiyuan 030001
Clc Number:R-33
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Abstract:

Depression has become the most common mental illnesses. Its incidence is increasing yearly and the cause remains unclear. Therefore, it is urgent to explore the pathogenesis of depression and find treatments. In recent years with the continuous increase of research related to depression, intestinal flora have become a new research hotspot in the pathogenesis of depression. Intestinal flora directly and indirectly affect brain functions through various mechanisms and regulate behaviors such as stress, anxiety and depression. This review discusses the relationship between intestinal flora and studies of animal models and clinical depression, the possible regulatory mechanism of intestinal flora in the occurrence and development of depression, and the anti-depressant mechanism of probiotics to provide a new theoretical basis for the treatment of depression by intestinal flora.

Key words:depression; intestinal flora; probiotics; regulatory mechanism

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Received:September 03,2021
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Online: May 08,2023
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