Research progress on molecular biology of gastroesophageal reflux disease

doi:10. 3969 / j.issn.1671-7856. 2022. 10. 020

Home > Archive>Volume 32, Issue 10, 2022 >148-154. DOI:10. 3969 / j.issn.1671-7856. 2022. 10. 020

Research progress on molecular biology of gastroesophageal reflux disease
DOI:
                        10. 3969 / j.issn.1671-7856. 2022. 10. 020
                    
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Author:
                        DONG MingmingDONG Mingming
Department of Gastroenterology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
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CHAI XiukunCHAI Xiukun
Department of Gastroenterology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
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LIU XuechenLIU Xuechen
Department of Gastroenterology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
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HE YunHE Yun
Department of Gastroenterology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
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LI AidiLI Aidi
Department of Gastroenterology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
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JIANG ShulinJIANG Shulin
Department of Gastroenterology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
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Affiliation:Department of Gastroenterology, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
Clc Number:R-33
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Abstract:

Gastroesophageal reflux disease ( GERD) is a common disease in gastroenterology, and clinical manifestations are prone to recurrent attacks. It is considered a risk factor for the development of esophageal adenocarcinoma( EAC). Family studies have shown that GERD heritability is approximately 30%, COL3A1 and ABAT genes are significantly associated with genetic risk. Several genes, such as the IL-1 gene cluster, GNB3 and GSTP1, are strongly associated with the risk of GERD. Mutations in TP53 and single nucleotide polymorphisms of EGF, MMP, CCND1, CDX2 and COX-2 cause genomic instability and promote the development of Barrett’s esophagus and EAC in some individuals. This article reviews the role of molecular biology in the occurrence and development of GERD into EAC.

Key words:gastroesophageal reflux disease; Barrett’s esophagus; esophageal adenocarcinoma; molecular biology; genetic risk loci; single nucleotide polymorphisms

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Received:January 27,2022
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Online: May 08,2023
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