Research progress on subgenome of beta-coronavirus

doi:10. 3969 / j.issn.1671-7856. 2022. 11. 019

Home > Archive>Volume 32, Issue 11, 2022 >142-148. DOI:10. 3969 / j.issn.1671-7856. 2022. 11. 019

Research progress on subgenome of beta-coronavirus
DOI:
                        10. 3969 / j.issn.1671-7856. 2022. 11. 019
                    
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Author:
                        ZHANG YaqingZHANG Yaqing
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center,Peking Union Medical Collage (PUMC);NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases;Key Laboratory of Human Diseases Animal Model, State Administration of Traditional Chinese Medicine, Beijing 100021, China
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QI FeifeiQI Feifei
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center,Peking Union Medical Collage (PUMC);NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases;Key Laboratory of Human Diseases Animal Model, State Administration of Traditional Chinese Medicine, Beijing 100021, China
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BAO LinlinBAO Linlin
Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center,Peking Union Medical Collage (PUMC);NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases;Key Laboratory of Human Diseases Animal Model, State Administration of Traditional Chinese Medicine, Beijing 100021, China
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Affiliation:Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center,Peking Union Medical Collage (PUMC);NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Key Laboratory for Animal Models of Emerging and Reemerging Infectious;Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases;Key Laboratory of Human Diseases Animal Model, State Administration of Traditional Chinese Medicine, Beijing 100021, China
Clc Number:R-33
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Abstract:

Five of seven coronaviruses that cause respiratory disease in humans were beta-coronaviruses. HCoVOC43 and HCoV-HKU1 show seasonal transmission and cause mild symptoms after infection. SARS-CoV, MERS-CoV and SARS-CoV-2 spread rapidly from person to person, which posed a serious threat to public health security and national economy. Nucleic acid testing is the key test to identify, diagnose and screen people infected by virus, but the positive of viral loads does not mean the virus is contagious. It is urgenly to explore a rapid detecting method for virus replication as a supplement to judge virus activity. Studies have confirmed that the subgenomes produced by beta-coronaviruses during cell replication can be used as indicators for judging viral activity. This paper reviews the detection and application of subgenomes of beta-coronavirus, aiming to establish subgenome detection method , optimize virus detection method , perfect experimental animal model creation and drug or vaccine effectiveness evaluation systems and help to carry out experimental research.

Key words:beta coronavirus; subgenome; virus replication; detection method

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Received:April 20,2022
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Online: January 18,2023
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