Objective To explore a safe, stable and repeatable model of gouty arthritis (GA) with damp-heat syndrome by comparing changes in lipid metabolism and proinflammatory factors between two rat models of GA with damp- heat. Methods Overall, 44 male SD rats were randomly divided into a control group ( n= 10), GA group ( n= 10), model group A (n= 12) and model group B (n= 12). The specific method was provided in full text, and the experimental period lasted for 21 days. The general condition of rats in each group was observed during the modeling period and the mortality rate was assessed after modeling. Ankle swelling was measured by the circumference method . Serum contents of lipid metabolism factors (TG, TC, LDL-C and HDL-C) and proinflammatory factors (NF-κB, IL-1β, TNF-α and IL-6) were determined by ELISA. Results The mortality rate was 8. 3% (1 / 12) in model group A and 25% (3 / 12) in model group B. Compared with control and GA groups, the serum TG, TC, and LDL-C were significantly higher in the model group A and B (P<0. 01), while HDL-C was decreased significantly (P<0. 01). Compared with model group A, TG and HDL-C were increased in the model group B, while TC and LDL-C were decreased, but without statistical significance (P>0. 05). Compared with the control group, serum NF-κB, IL-1β, IL-6 and TNF-α were significantly higher in the GA group, and model group A and B (P<0. 01). Compared with the GA group, NF-κB and TNF-α were increased in the model group A (P<0. 05), and NF-κB, IL-1β, IL-6 and TNF-α were increased in model group B (P<0. 05). Compared with model group A, IL-1β, IL-6 and TNF-α were increased in model group B ( P< 0. 05 ). Conclusions Both approaches successfully induced a combined model of GA with damp-heat syndrome. Both of them had commonalities and individualities. The high fat and sugar diet was a directly influencing factor for lipid metabolism disorder. Biological factors had more obvious effects on inflammation in rats than a high temperature and humidity environment.