Establishment and evaluation of rat model of allergic asthma

doi:10. 3969 / j.issn.1671-7856. 2023. 01. 017

Home > Archive>Volume 33, Issue 1, 2023 >130-137. DOI:10. 3969 / j.issn.1671-7856. 2023. 01. 017

Establishment and evaluation of rat model of allergic asthma
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                        10. 3969 / j.issn.1671-7856. 2023. 01. 017
                    
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                        LOU Jincheng1,2,1LOU Jincheng
Shanxi University of Traditional Chinese Medicine, Jinzhong 030600, China
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MIAO Xinyun1,2,1MIAO Xinyun
Shanxi University of Traditional Chinese Medicine, Jinzhong 030600, China
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SU Jiaqi1,2,1SU Jiaqi
Shanxi University of Traditional Chinese Medicine, Jinzhong 030600, China
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HU Qing1,2,1HU Qing
Shanxi University of Traditional Chinese Medicine, Jinzhong 030600, China
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ZHAI Chuntao1,2,1ZHAI Chuntao
Shanxi University of Traditional Chinese Medicine, Jinzhong 030600, China
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LYU Yue2LYU Yue
Shanxi Province Acupuncture Hospital, Taiyuan 030006
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Affiliation:1. Shanxi University of Traditional Chinese Medicine, Jinzhong 030600, China. 2. Shanxi Province Acupuncture Hospital, Taiyuan 030006
Clc Number:R-33
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Abstract:

Allergic asthma is a chronic airway inflammatory disease caused by type 2 inflammatory response- mediated hypersensitivity. At present, no animal model of asthma that completely recapitulates the occurrence and development of allergic asthma in humans is available. Therefore, it is particularly important to establish a relatively complete and stable animal model of allergic asthma that conforms to the pathological manifestations of patients. This review briefly analyzes the strain selection, modeling method, and model evaluation indicators of allergic asthma model rats in the past 5 years.

Key words:allergic asthma; rat model; model establishment; evaluation index

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Received:May 19,2022
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Online: March 16,2023
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