Research progress on the relationship between ferroptosis and immune cells

doi:10. 3969 / j.issn.1671-7856. 2023. 03. 012

Home > Archive>Volume 33, Issue 3, 2023 >90-97. DOI:10. 3969 / j.issn.1671-7856. 2023. 03. 012

Research progress on the relationship between ferroptosis and immune cells
DOI:
                        10. 3969 / j.issn.1671-7856. 2023. 03. 012
                    
CSTR:
                        [cstr]
                    
Author:
                        ZHANG GuihongZHANG Guihong
1. Institute of Biochemistry and Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China.2. Collaborative Innovation Center for Antitumor Active Substance Research and Development, Guangdong MedicalUniversity, Zhanjiang 524023. 3. School of Medical Technology, Guangdong Medical University, Dongguan 523808
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site
TANG XudongTANG Xudong
1. Institute of Biochemistry and Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China.2. Collaborative Innovation Center for Antitumor Active Substance Research and Development, Guangdong MedicalUniversity, Zhanjiang 524023. 3. School of Medical Technology, Guangdong Medical University, Dongguan 523808
Find this author on All Journals
Find this author on BaiDu
Search for this author on this site

                    
Affiliation:1. Institute of Biochemistry and Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China.2. Collaborative Innovation Center for Antitumor Active Substance Research and Development, Guangdong MedicalUniversity, Zhanjiang 524023. 3. School of Medical Technology, Guangdong Medical University, Dongguan 523808
Clc Number:R-33
Fund Project:

Article

Figures

Metrics

Reference

Cited by

Materials

Comments

Abstract:

Ferroptosis is novel iron-dependent programmed cell death characterized by excessive accumulation of reactive oxygen species and lipid peroxidation. In recent years, an increasing number of studies have focused on the roles of immunomodulation in ferroptosis. Immune cells are the most important part of the immune system. This review discusses the current research progress on the relationship between ferroptosis and immune cells. The role of glutathione peroxidase 4 (Gpx4) in immune cell proliferation and the immune response is summarized. Ferroptosis releases various molecules including damage-associated molecular patterns, which influences the differentiation and function of immune cells and thereby affects disease progression. Moreover, immune factors or their metabolites secreted by immune cells affect the occurrence of ferroptosis. This review concludes with a brief summary and outlook for future research, which may be helpful to guide the direction of disease treatment.

Key words:ferroptosis; immune cells; glutathione peroxidase 4; damage-associated molecular patterns

Get Citation

Copy

Article Metrics

Abstract:
PDF:
HTML:
Cited by:

History

Received:June 29,2022
Revised:
Adopted:
Online: April 13,2023
Published:

Home

About this journal

Editorial Board

Info for Author

Contact Us

中文版

Get Citation

Share

Article Metrics

History

Article QR Code