Abstract:The rabbit is a classical animal model in biomedical research. The development of genetically modified rabbit models has been severely impeded because of the lack of pluripotent stem cells and the extremely low efficiency of somatic cell nuclear transfer. With the rapid development of novel genome-editing techniques, such as ZFNs, TALENs, and CRISPR/ Cas9, genetic engineering of rabbits has developed rapidly. Genetically modified rabbit models are playing increasingly important roles in the field of biomedicine. In this review, we discuss the development of genetically modified rabbit models and their applications in human disease research to provide a theoretical reference for promoting the development of human disease animal models.