Research progress of brain astrocyte-neuron interactions involved in the pathogenesis of depression

doi:10. 3969 / j.issn.1671-7856. 2023. 03. 016

Home > Archive>Volume 33, Issue 3, 2023 >124-129. DOI:10. 3969 / j.issn.1671-7856. 2023. 03. 016

Research progress of brain astrocyte-neuron interactions involved in the pathogenesis of depression
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                        10. 3969 / j.issn.1671-7856. 2023. 03. 016
                    
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                        LIU YanLIU Yan
1. Academy of Chinese Medical Sciences, Henan Key Laboratory of Traditional Chinese Medicine Prescription and Syndrome Signaling, Henan University of Chinese Medicine, Zhengzhou 450046, China.
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PENG MengweiPENG Mengwei
1. Academy of Chinese Medical Sciences, Henan Key Laboratory of Traditional Chinese Medicine Prescription and Syndrome Signaling, Henan University of Chinese Medicine, Zhengzhou 450046, China.
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ZHANG WenxianZHANG Wenxian
2. Traditional Chinese Medicine School, Henan University of Chinese Medicine, Zhengzhou 450046.
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YANG TiezhuYANG Tiezhu
3. Intensive Care Unit, Luoyang Orthopedic Hospital of Henan Province (Orthopedic Hospital of Henan Province), Zhengzhou 450000
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WU YaosongWU Yaosong
1. Academy of Chinese Medical Sciences, Henan Key Laboratory of Traditional Chinese Medicine Prescription and Syndrome Signaling, Henan University of Chinese Medicine, Zhengzhou 450046, China.
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LIU JunLIU Jun
1. Academy of Chinese Medical Sciences, Henan Key Laboratory of Traditional Chinese Medicine Prescription and Syndrome Signaling, Henan University of Chinese Medicine, Zhengzhou 450046, China.
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REN ShanshanREN Shanshan
1. Academy of Chinese Medical Sciences, Henan Key Laboratory of Traditional Chinese Medicine Prescription and Syndrome Signaling, Henan University of Chinese Medicine, Zhengzhou 450046, China.
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CHEN YulongCHEN Yulong
1. Academy of Chinese Medical Sciences, Henan Key Laboratory of Traditional Chinese Medicine Prescription and Syndrome Signaling, Henan University of Chinese Medicine, Zhengzhou 450046, China.
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Affiliation:1. Academy of Chinese Medical Sciences, Henan Key Laboratory of Traditional Chinese Medicine Prescription and Syndrome Signaling, Henan University of Chinese Medicine, Zhengzhou 450046, China. 2. Traditional Chinese Medicine School, Henan University of Chinese Medicine, Zhengzhou 450046. 3. Intensive Care Unit, Luoyang Orthopedic Hospital of Henan Province (Orthopedic Hospital of Henan Province), Zhengzhou 450000
Clc Number:R-33
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Abstract:

The classical view is that astrocytes are support cells of neurons and have no direct role in brain information processing. Accumulating evidence indicates that neuron-astrocyte signaling dysfunction may be related to the pathology of various neurological and neurodegenerative diseases. This has gradually become a hot topic in the study of depression pathogenesis in recent years. This review summarizes the evidence that astrocyte-neuron communication is involved in brain oxidative defense, synaptic plasticity, brain energy metabolism, neuroinflammation, and glutamate cycling in depression. Such evidence suggests that dysfunction of astrocyte-neuron communication crosstalk is a major mechanism in the pathogenesis of depression. This review also discusses the recent view that astrocyte-neuron interactions are involved in the pathogenesis of depression, as well as the existing problems in the research, to provide ideas and references for subsequent research.

Key words:astrocytes; neurons; interactions; depression; research progress

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Received:May 17,2022
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Online: April 13,2023
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