Structure and function of FEM1B in cancer and HIV infection

doi:10. 3969 / j.issn.1671-7856. 2023. 05. 014

Home > Archive>Volume 33, Issue 5, 2023 >112-117. DOI:10. 3969 / j.issn.1671-7856. 2023. 05. 014

Structure and function of FEM1B in cancer and HIV infection
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                        10. 3969 / j.issn.1671-7856. 2023. 05. 014
                    
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                        YANG ChenboYANG Chenbo
Comparative Medicine Center, Peking Union College (PUMC)&Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
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CONG ZheCONG Zhe
Comparative Medicine Center, Peking Union College (PUMC)&Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
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XUE JingXUE Jing
Comparative Medicine Center, Peking Union College (PUMC)&Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
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Affiliation:Comparative Medicine Center, Peking Union College (PUMC)&Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
Clc Number:R-33
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Abstract:

FEM1B is a highly conserved gene, and the protein encoded by FEM1B is a member of the anchorrepeat protein family. Its spatial conformation contains 7 modules in series. FEM1B is involved in the regulation of a variety of biological functions, including apoptosis, protein ubiquitination modification, cell reductive stress and DNA replication stress. FEM1B has been shown to promote apoptosis of tumor cells in colorectal cancer, human T-cell acute lymphoblastic leukemia, and diffuse large B-cell lymphoma, while downregulation of FEM1B inhibits proliferation, invasion, and migration of tumor cells in non-small cell lung cancer. In addition, the structure of FEM1B is related to the HIV regulatory protein Vif. These characteristics of FEM1B may make it a new target for cancer treatment and the regulation of HIV infection.

Key words:FEM1B; apoptosis; ubiquitination; reductive stress reaction; cancer; HIV

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Received:November 22,2022
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Online: June 15,2023
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