Literature review of animal models of depression induced by drugs
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1. Hunan Engineering Technology Research Center for Medicinal and Functional Food, Changsha 410208, China.2. Institute of Medicinal Plant Development Chinese Academy of Medical Science and Peking Union Medical Medical College, Bejing 100193. 3. Key Laboratory of TCM Heart and Lung Syndrome Differentiation & Medicated Diet and Dietotherapy, Hunan University of Chinese Medicine, Changsha 410208. 4. Provincial Key Laboratory of TCM Diagnostics, Hunan University of Chinese Medicine, Changsha 410208. 5. Hunan University of Chinese Medicine, Changsha 410208. 6. Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Beijing 100193

Clc Number:

R-33

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    Abstract:

    Depression is a disease that seriously endangers human physical and mental health. The establishment of a suitable animal model of depression is of great significance to study its pathogenesis and develop drugs. Among the animal models of depression, animal models of drug-induced depression are widely used because of the advantages of simplicity and timely establishment. This article systematically reviewed drug-induced depression animal models in the China National Knowledge Network and PubMed until July 1, 2021, and reviewed six commonly used drug-induced depression animal models. The frequency of use of induced depression animal models, selection of model animals, drug injection dosage, injection method , indicators for model evaluation, advantages, and disadvantages are expected to provide references to prepare depression models and develop drugs.

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History
  • Received:November 05,2021
  • Online: June 15,2023
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