FEM1B promotes cell apoptosis induced by TRAIL in HIV reservoir ACH-2 cell lines

doi:10. 3969 / j.issn.1671-7856. 2023. 05. 001

Home > Archive>Volume 33, Issue 5, 2023 >1-7. DOI:10. 3969 / j.issn.1671-7856. 2023. 05. 001

FEM1B promotes cell apoptosis induced by TRAIL in HIV reservoir ACH-2 cell lines
DOI:
                        10. 3969 / j.issn.1671-7856. 2023. 05. 001
                    
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Author:
                        YANG ChenboYANG Chenbo
Comparative Medicine Center, Peking Union College (PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
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LU JiahanLU Jiahan
Comparative Medicine Center, Peking Union College (PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
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CONG ZheCONG Zhe
Comparative Medicine Center, Peking Union College (PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
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XUE JingXUE Jing
Comparative Medicine Center, Peking Union College (PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
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Affiliation:Comparative Medicine Center, Peking Union College (PUMC) & Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS); NHC Key Laboratory of Human Disease Comparative Medicine; Key Laboratory of Human Diseases Animal Models, State Administration of Traditional Chinese Medicine; Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious Diseases, Beijing 100021, China
Clc Number:R-33
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Abstract:

Objective To study the role and effect of FEM1B in apoptosis of HIV reservoir ACH-2 cell lines. Methods A lentivirus used to overexpress FEM1B in ACH-2 cell lines. FITC-annexin-V/7-AAD staining was used to assess spontaneous cell apoptosis and cell apoptosis under TRAIL stimulation. Viral loads in culture supernatants were examined by qPCR. Results Spontaneous cell apoptosis remained unchanged in FEM1B-overexpressing cell lines. Cell apoptosis and viral loads in culture supernatants under TRAIL stimulation were significantly increased. Conclusions FEM1B increases TRAIL-mediated cell apoptosis and viral loads in culture supernatants of HIV reservoir cell lines.

Key words:cell apoptosis; FEM1B; TRAIL; HIV reservoir

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Received:January 12,2023
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Online: June 15,2023
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