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Home > Archive>Volume 33, Issue 6, 2023 >120-127. DOI:10. 3969 / j.issn.1671-7856. 2023. 06. 017
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Research progress on animal and cell models of nonalcoholic fatty liver disease
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Affiliation:

1. Ruikang Clinical Medical College, Guangxi University of Chinese Medicine, Nanning 530001, China. 2. School of Nursing, Guangxi University of Traditional Chinese Medicine, Nanning 530200. 3. School of Nursing, Suzhou University, Suzhou 215006. 4. the First School of Clinical Medicine, Guangxi University of Chinese Medicine, Nanning 530001. 5. Basic Medical College, Guangxi University of Traditional Chinese Medicine, Nanning 530200

Clc Number:

R-33

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    Abstract:

    The modeling method of non-alcoholic fatty liver has always been a research focus. The selection of appropriate animal and cell models in accordance with experimental purposes is of great significance to study the pathogenesis of non-alcoholic fatty liver disease. The commonly used modeling method are high fat and sugar feeding, choline-methionine deficiency, drug induction, and saturated or unsaturated fatty acid induction. Rats, mice, genemodified mice, and cells are most frequently used to model non-alcoholic fatty liver. This review focuses on the research progress of rats, mice, genetically defective mice, and cell models of non-alcoholic fatty liver.

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  • Received:October 28,2022
  • Online: August 18,2023
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