Vascular endothelial dysfunction and its functional assessment

doi:10. 3969 / j.issn.1671-7856. 2023. 07. 017

Home > Archive>Volume 33, Issue 7, 2023 >130-140. DOI:10. 3969 / j.issn.1671-7856. 2023. 07. 017

Vascular endothelial dysfunction and its functional assessment
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                        10. 3969 / j.issn.1671-7856. 2023. 07. 017
                    
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                        TIAN Jing2,3,1TIAN Jing
1. Shandong First Medical University, Jinan 250013, China. 2. Jinan Central Hospital, Jinan 250013.
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MA Yingjie2,3,1MA Yingjie
1. Shandong First Medical University, Jinan 250013, China. 2. Jinan Central Hospital, Jinan 250013.
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WANG Peng2,3,1WANG Peng
1. Shandong First Medical University, Jinan 250013, China. 2. Jinan Central Hospital, Jinan 250013.
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LI Yang2,3,1LI Yang
1. Shandong First Medical University, Jinan 250013, China. 2. Jinan Central Hospital, Jinan 250013.
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ZENG Lu2,3,1ZENG Lu
2. Jinan Central Hospital, Jinan 250013.
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LI BinLI Bin
1. Shandong First Medical University, Jinan 250013, China. 2. Jinan Central Hospital, Jinan 250013. 3. Research Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical University, Jinan 250013
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SU GuohaiSU Guohai
1. Shandong First Medical University, Jinan 250013, China. 2. Jinan Central Hospital, Jinan 250013. 3. Research Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical University, Jinan 250013
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Affiliation:1. Shandong First Medical University, Jinan 250013, China. 2. Jinan Central Hospital, Jinan 250013. 3. Research Center of Translational Medicine, Central Hospital Affiliated to Shandong First Medical University, Jinan 250013
Clc Number:R-33
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Abstract:

Vascular endothelial cells form a thin layer of flattened cells that cover the surface of the vessel wall, As an effector tissue, the vessel wall responds to various stimuli to release vasoactive substances to maintain homeostasis. However, endothelial cells are prone to dysfunction induced by multiple pathological factors, which is manifested by an impaired vasomotor function, thrombosis, and arterial wall proliferation. Studies have shown that vascular endothelial dysfunction is closely related to the occurrence and development of cardiovascular diseases such as atherosclerosis and heart failure. Therefore, effectively evaluating endothelial functions is essential to prevent and treat cardiovascular diseases. In this review, we discuss the functions and regulatory principles of the vascular endothelium and its relationship with cardiovascular diseases and summarize the basic principles and advantages and disadvantages of existing endothelial assessment techniques to assist in the diagnosis and treatment of cardiovascular diseases.

Key words:vascular endothelial dysfunction; nitric oxide;rein-angiotensin system; reactive oxygen species; flowmediated vasodilation; optical coherence tomography

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Received:October 24,2022
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Online: August 18,2023
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