IMPDH2 expression in the temporal cortex in a rhesus macaque with chronic SHIV KU-1 infection

doi:10. 3969 / j.issn.1671-7856. 2023. 07. 005

Home > Archive>Volume 33, Issue 7, 2023 >34-40. DOI:10. 3969 / j.issn.1671-7856. 2023. 07. 005

IMPDH2 expression in the temporal cortex in a rhesus macaque with chronic SHIV KU-1 infection
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                        10. 3969 / j.issn.1671-7856. 2023. 07. 005
                    
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                        ZHAO Changcheng2,1ZHAO Changcheng
1. Infectious Disease Hospital, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230022, China.
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DING Huaming2,1DING Huaming
1. Infectious Disease Hospital, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230022, China.
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LU Lunshan2,1LU Lunshan
1. Infectious Disease Hospital, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230022, China.
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ZHANG Qian2,1ZHANG Qian
1. Infectious Disease Hospital, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230022, China.
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YANG Jing2,1YANG Jing
1. Infectious Disease Hospital, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230022, China.
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DONG Ying2,1DONG Ying
1. Infectious Disease Hospital, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230022, China.
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XUE Qunshan2,1XUE Qunshan
1. Infectious Disease Hospital, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230022, China.
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ZHUANG KeZHUANG Ke
2. Center for Animal Experiment, Wuhan University, Wuhan 430071
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Affiliation:1. Infectious Disease Hospital, the First Affiliated Hospital of University of Science and Technology of China, Hefei 230022, China. 2. Center for Animal Experiment, Wuhan University, Wuhan 430071
Clc Number:R-33
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Abstract:

Objective To investigate the effect of HIV infection on inosine-5’-monophosphate dehydrogenase 2(IMPDH2) expression in the cerebral temporal cortex. Methods Montreal Cognitive Assessment (MoCA) scores and magnetic resonance imaging were used to assess mild cognitive impairment in HIV-infected patients. In addition, the histologic structure of the temporal cortex in a rhesus macaque with chronic simian-human immunodeficiency virus (SHIV) KU-1 infection was examined using hematoxylin and eosin staining. Moreover, IMPDH2 protein expression levels in paired healthy and infected temporal cortex were examined using immunohistochemistry and Western blot. Finally, putative genes associated with IMPDH2 expression were investigated using protein-protein interaction network analysis. Results HIV positive individuals had a thinner temporal cortex compared with healthy controls. In addition, the numbers of neurons in the temporal cortex were decreased and IMPDH2 protein levels were significantly lower in the infected monkey compared with healthy controls. Eight genes interacting with the IMPDH2 gene were identified. Conclusions Downregulation of IMPDH2 protein in the temporal cortex might be involved in the pathogenesis of HIV-related neurocognitive disease.

Key words:HIV-associated neurocognitive disorder; IMPDH2; temporal cortex; SHIV KU-1 infecion; rhesus macaque

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Received:June 20,2022
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Online: August 18,2023
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