+Advanced Search
Home > Archive>Volume 33, Issue 8, 2023 >147-152. DOI:10. 3969 / j.issn.1671-7856. 2023. 08. 020
PDF HTML XML Export Cite reminder
Research progress on the pathogenesis and related signal transduction mechanisms of liver fibrosis
CSTR:
[cstr]
Author:
Affiliation:

1. Department of Pharmacy, the Second People’s Hospital of Hefei (Hefei Hospital of Anhui Medical University), Hefei 230011, China. 2. Department of General Surgery, People’s Hospital of Fengyang County, Chuzhou 233100

Clc Number:

R-33

  • Article
    • | |
  • Metrics
    • |
  • Reference
    • |
  • Related
    • |
  • Cited by
    • | |
  • Comments
    Abstract:

    Cirrhosis is caused by an imbalance of hyperplasia and extracellular matrix decomposition in the liver for various reasons, and it is a major link between various liver diseases to the development of cirrhosis. The process of liver fibrosis is reversible. Liver injury leads to activation of hepatic stellate cells to form muscle fibrocytes, excessive extracellular matrix deposition in the liver, and then liver fibrosis. Its consequences often lead to irreversible cirrhosis and even liver cancer. The specific pathogenesis and molecular signal transduction mechanism of liver fibrosis are unclear. Therefore, it is important to explore the pathogenesis of hepatic fibrosis and investigate anti-fibrotic target drugs. To this end, this article reviews the pathogenesis of liver fibrosis and the related signal transduction studies.

    Reference
    Related
    Cited by
Get Citation

Copy
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
History
  • Received:November 18,2022
  • Online: November 09,2023
Article QR Code
You are the first Visitors
® 2025 All Rights Reserved
Address：5 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China Postcode： Phone：86-10-67779337 E-mail:bjb@cnilas.org
Supported by:Beijing E-Tiller Technology Development Co., Ltd.