Keratitis is a common ophthalmic disease with a high rate of blindness. This article reviews the relevant literature on animal models of keratitis, summarizes and analyzes the mechanisms of existing animal models of keratitis, and evaluates the clinical anastomosis degree of traditional Chinese and Western medicines in combination with the established clinical diagnostic standards of traditional Chinese and Western medicines, analyzes their advantages and disadvantages, and provides suggestions. Most existing models are based on Western medical theories and lack the diagnostic standards of traditional Chinese medicine. The model is mostly established by a single factor that cannot simulate the actual lesion process of the disease. Diagnosis of the model lacks apparent indicators. It is recommended that animals are modeled by combining disease evidence. It is very important to prepare animal models of keratitis with high clinical compatibility and establish efficient evaluation standards to better understand the occurrence and development of keratitis in modern medical experiments and effectively prevent and treat the disease.