Animal models are important means for basic research in traditional Chinese medicine (TCM). Qi deficiency, dampness, and blood stasis are the main syndromes of renal fibrosis. With the increase in the morbidity and mortality of chronic kidney disease, study of renal fibrosis animal models of qi deficiency and dampness stasis syndrome has become a hotspot in recent years. Additionally, establishment of combined disease and syndrome animal models is urgently needed. This article reviews the recent modeling method that established the renal fibrosis pathological model based on western medicine surgery and chemical factors, and established the model of qi deficiency, dampness and blood stasis disease from the aspect of etiology and pathology through the theory of exhaustion leading to qi loss or hunger leading to qi loss, internal and external dampness combination, exogenous pathogenic factors, and chemical drugs. Additionally, these studies established the evaluation standard of the renal fibrosis animal model of qi deficiency, dampness and blood stasis type from the aspects of macroscopic characterization, laboratory indexes, and pathological changes. The TCM disease and syndrome model has been combined with modern science to establish a relatively perfect qi deficiency and dampness stasis kidney fibrosis animal model with evaluation criteria. Exploring its pathogenesis and new treatments supports the therapeutic role of TCM in kidney fibrosis and promotes TCM internationally.