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Home > Archive>Volume 33, Issue 10, 2023 >106-113. DOI:10. 3969 / j.issn.1671-7856. 2023. 10. 014
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Research progresses on the effects of high altitude on mitochondrial function and energy metabolism
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1.College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, China. 2. the PLA Highland Medical Laboratory, the 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation Army, Lanzhou 730050. 3. Institute of Radiation Medicine Sciences, Academy of Military Medical, Academy of Military Sciences, Beijing 100850. 4. Gansu Plateau Pharmaceutical Technology Center, Lanzhou 730050

Clc Number:

R-33

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    Abstract:

    A high altitude plateau is a unique environment with low pressure, oxygen, and temperature. The plateau environment reduces the metabolism of energy substances and mitochondrial functions, thereby affecting work on a plateau. In recent years, mitochondrial damage has attracted broad attention. As the energy factory of cells, mitochondria are closely linked to body movement. We focused our attention on mitochondrial damage at high altitude and summarized the effects of high altitude on the metabolism of basic energy substances and changes in important enzyme activities and the mitochondrial structure and function in the mitochondrial biochemical energy supply response. We found that protein, carbohydrate and lipid metabolism was negatively affected at high altitude, resulting in fatigue, hyperlipidemia, and body repair. The activities of enzymes related to pyruvate metabolism, the tricarboxylic acid cycle, β-oxidation, and oxidative phosphorylation were inhibited, and the morphology and number of mitochondria were changed, leading to impaired mitochondrial functions and affecting exercise energy supply. Exploration of the mechanism of cell injury at high altitude may promote research to prevent and treat such injuries.

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History
  • Received:February 13,2023
  • Online: December 29,2023
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