Chronic obstructive pulmonary disease (COPD) is a common respiratory disease with high morbidity and mortality, and has become a major health issue. Traditional Chinese medicine has accumulated rich historical experience in the treatment of COPD and has unique clinical advantages. To further explore the therapeutic effect of traditional Chinese medicine on this disease, establishment of a COPD animal model combining disease and syndrome is critical to study occurrence and development of the disease. The combined models of disease and syndrome summarized include five types: the animal model of lung qi deficiency, the animal model of lung and spleen deficiency, the animal model of phlegm-heat stagnation of lung, the animal model of phlegm-stasis obstructing lung, and the animal model of cold-fluid syndrome. The common disease and syndrome in recent years combined with the method of class modeling are simply described and combined to provide new ideas for researchers and promote research of traditional Chinese medicine of this disease.