Research progress of exosomal miRNA in early screening and treatment of Alzheimer’s disease

doi:10. 3969 / j.issn.1671-7856. 2023. 10. 018

Home > Archive>Volume 33, Issue 10, 2023 >140-145. DOI:10. 3969 / j.issn.1671-7856. 2023. 10. 018

Research progress of exosomal miRNA in early screening and treatment of Alzheimer’s disease
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                        10. 3969 / j.issn.1671-7856. 2023. 10. 018
                    
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                        ZHANG JunfengZHANG Junfeng
Department of Basic Medicine, Medical College, Pingdingshan University, Pingdingshan 467000, China
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HAO LiyaHAO Liya
Department of Basic Medicine, Medical College, Pingdingshan University, Pingdingshan 467000, China
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GAO HongyanGAO Hongyan
Department of Basic Medicine, Medical College, Pingdingshan University, Pingdingshan 467000, China
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LIU GuangfuLIU Guangfu
Department of Basic Medicine, Medical College, Pingdingshan University, Pingdingshan 467000, China
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ZHANG ZuyuanZHANG Zuyuan
Department of Basic Medicine, Medical College, Pingdingshan University, Pingdingshan 467000, China
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GUO YonggangGUO Yonggang
Department of Basic Medicine, Medical College, Pingdingshan University, Pingdingshan 467000, China
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Affiliation:Department of Basic Medicine, Medical College, Pingdingshan University, Pingdingshan 467000, China
Clc Number:R-33
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Abstract:

Exosomes are small molecule extracellular vesicles secreted by various cells and play a major role in the pathological process of Alzheimer’s disease by transporting various bioactive substances such as miRNAs. Expression of exosomal miRNA changes in the early stages of AD, and exogenous injection of mesenchymal stem cell-derived exosomal miRNA improves learning and memory of AD animal models. This article reviews the research progress of exosomes in early screening and treatment of Alzheimer’s disease.

Key words:exosomes; miRNA; Alzheimer’s disease; mesenchymal stem cell

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Received:January 03,2023
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Online: December 29,2023
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