+Advanced Search
Home > Archive>Volume 33, Issue 10, 2023 >1-7. DOI:10. 3969/ j.issn.1671-7856. 2023. 10. 001
PDF HTML XML Export Cite reminder
Left-to-right shunt slows cardiac remodeling in rats with pulmonary hypertension
Author:
Affiliation:

1.Baotou Medical College of Inner Mongolia University of Science and Technology, Baotou 014040, China. 2. Chinese Academy of Medical Sciences, Peking Union Medical College, Key Laboratory of Pulmonary Vascular Medicine of Fuwai Hospital, State Key Laboratory of Cardiovascular Diseases, National Center of Cardiovascular Diseases, Beijing 100037. 3. Department of Cardiology, Second Affiliated Hospital of Baotou Medical College, Baotou 014030. 4. Department of General Medicine, Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016. 5. Quzhou Kecheng District People’s Hospital, Quzhou 324000

  • Article
    • | |
  • Metrics
    • |
  • Reference
    • |
  • Related
    • |
  • Cited by
    • | |
  • Comments
    Abstract:

    Objective The prognosis of patients with left-to-right shunt congenital heart disease-associated pulmonary hypertension is significantly better than that of patients with idiopathic pulmonary hypertension, but the specific mechanism is unclear. The purpose of this study was to establish a rat model of idiopathic pulmonary hypertension and congenital heart disease with pulmonary hypertension, and compare the similarities and differences between the two models in terms of pulmonary vascular remodeling and cardiac remodeling. Methods Male SD rats were divided into three groups: control group (n= 8), monocrotaline (MCT) group (50 mg/ kg) to simulate idiopathic pulmonary hypertension (n= 8), and cervical arteriovenous shunt surgery+monocrotaline (MCT) group (50 mg/ kg) to simulate left-to-right shunt congenital heart disease with pulmonary hypertension (n= 8). Three weeks after establishment of the model, echocardiography, left and right cardiac catheter pressure measurements, and lung histopathological staining were performed to compare cardiac and pulmonary phenotypes of the rats. Results Compared with the control group, no significant difference was found between the MCT and the operation+MCT groups in terms of the right ventricular hypertrophy, right ventricular dysfunction, mean pulmonary artery pressure, pulmonary vascular remodeling, or other indicators at 3 weeks after the operation. However, many indexes related to left heart in rats of the operation+MCT group were significantly better than those in the simple MCT group. Compared with that in the control group, the left ventricular lumen diameter (and left ventricular ejection fraction) in the operation+MCT group did not decrease in the diastolic period. The maximum rate of increase in right ventricular internal pressure and the maximum rate of decrease in left ventricular internal pressure in the operation+MCT group were lower than that in the simple MCT group. Conclusions Left-to-right shunt surgery cannot change MCT-induced pulmonary hypertension or right heart remodeling, but can produce left heart compensation, which may be beneficial to the prognosis of patients. The animal model of this study establishes the basis to examine various pathological mechanisms of idiopathic pulmonary hypertension and pulmonary hypertension associated with congenital heart disease.

    Reference
    Related
    Cited by
Get Citation

Copy
Related Videos

Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
History
  • Received:February 13,2022
  • Online: December 29,2023
Article QR Code
You are the first Visitors
® 2025 All Rights Reserved
Address：5 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China Postcode： Phone：86-10-67779337 E-mail:bjb@cnilas.org
Supported by:Beijing E-Tiller Technology Development Co., Ltd.