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Home > Archive>Volume 33, Issue 11, 2023 >110-117. DOI:10. 3969 / j.issn.1671-7856. 2023.11. 015
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Progress of research into the roles of miRNA in neuroprotection against ischemic stroke
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1.Henan University of Traditional Chinese Medicine, Zhengzhou 450000, China. 2. the First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450000. 3. the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450000

Clc Number:

R-33

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    Abstract:

    Ischemic stroke is a cerebrovascular disease that leads to high incidences of disability and mortality and can be life-threatening in severe cases, thus, it has a heavy social and economic burden worldwide. The etiology and pathological processes of ischemic stroke are mediated by a variety of molecular processes, some of which are dynamically regulated after transcription. Increasing evidence has shown that micro ( mi)-RNA, as important mediators of posttranscriptional gene silencing, play crucial roles in gene expression and the pathological processes of ischemic stroke. In this review, we discuss the neuroprotective effects of miRNAs in the different mechanisms involved in ischemic stroke. As the promotion or inhibition of miRNA expression through specific drug and non-drug therapies may be beneficial to the recovery of ischemic stroke, the use of miRNA in clinical diagnosis and treatment are also discussed in detail in this paper. This article aims to provide a reference for further clinical and basic research in this field.

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History
  • Received:April 13,2023
  • Online: December 29,2023
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