Application research progress of single cell RNA-sequencing technology in neurodegenerative diseases

doi:10. 3969 / j.issn.1671-7856. 2023. 11. 013

Home > Archive>Volume 33, Issue 12, 2023 >86-92. DOI:10. 3969 / j.issn.1671-7856. 2023. 11. 013

Application research progress of single cell RNA-sequencing technology in neurodegenerative diseases
DOI:
                        10. 3969 / j.issn.1671-7856. 2023. 11. 013
                    
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                        WU Jianfei1WU Jianfei
1.Zigong Psychiatric Research Center Zigong Institute of Brain Science, Zigong 643020, China
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LIU Yu1LIU Yu
1.Zigong Psychiatric Research Center Zigong Institute of Brain Science, Zigong 643020, China
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WEI Daixu1,2WEI Daixu
1.Zigong Psychiatric Research Center Zigong Institute of Brain Science, Zigong 643020, China. 2. Department of Life Sciences and Medicine, Northwest University, Xi’an 710069
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PU Jianlin1PU Jianlin
1.Zigong Psychiatric Research Center Zigong Institute of Brain Science, Zigong 643020, China
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CAI Duanfang1CAI Duanfang
1.Zigong Psychiatric Research Center Zigong Institute of Brain Science, Zigong 643020, China
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WANG Binglong1WANG Binglong
1.Zigong Psychiatric Research Center Zigong Institute of Brain Science, Zigong 643020, China
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Affiliation:1.Zigong Psychiatric Research Center Zigong Institute of Brain Science, Zigong 643020, China. 2. Department of Life Sciences and Medicine, Northwest University, Xi’an 710069
Clc Number:R-33
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Abstract:

Neurodegenerative diseases (NDs) are closely related to the central nervous system and characterized by morphological abnormalities and progressive loss of function in specific neuron groups. The main NDs include Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, multiple sclerosis and Huntington’ s disease. However, no direct therapies for NDs exist. In recent years, single cell RNA-sequencing (scRNA-seq) has been widely used in various NDs. The pathogenesis of NDs is closely related to morphology of immune cells, and the pathogenesis mainly involves mitochondrial function, glucose metabolism, inflammation, and synaptic transmission. Induced pluripotent stem cells are a potential therapy for NDs. Ultimately, we review the application of scRNA-seq to various NDs and provide a reference for prevention and treatment of NDs.

Key words:neurodegenerative diseases; single cell RNA-sequencing; central nervous system; pathogenesis

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Received:March 15,2023
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Online: January 22,2024
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