Research progress on the role of autophagy in the pathogenesis of systemic sclerosis
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1.Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014010, China.2.Department of Rheumatology, the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014010. 3.Central Laboratory of the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology (Key Laboratory of Autoimmunity of Inner Mongolia), Baotou 014010

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R-33

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    Abstract:

    Systemic sclerosis (SSc) is an autoimmune disease characterized by vascular lesions and skin fibrosis, which causes structural and functional damage to multiple organs. The pathogenesis of SSc is complex and may be related to genetic and environmental factors as well as abnormal immune mechanisms. Autophagy is an evolutionarily conserved process of self-degradation in the body and participates in the pathogenesis of autoimmune diseases through various pathways. This article reviews the research progress on the role of autophagy in the angiopathy and fibrosis of SSc by regulating immune cells and mediating signaling pathways.

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History
  • Received:February 01,2023
  • Online: January 22,2024
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