Research progress on modeling methods and evaluation indexes of kidney injury in zebrafish

doi:10. 3969 / j.issn.1671-7856. 2023. 11. 019

Home > Archive>Volume 33, Issue 12, 2023 >123-126. DOI:10. 3969 / j.issn.1671-7856. 2023. 11. 019

Research progress on modeling methods and evaluation indexes of kidney injury in zebrafish
DOI:
                        10. 3969 / j.issn.1671-7856. 2023. 11. 019
                    
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Author:
                        LAN AilinLAN Ailin
Guizhou Provincial Key Laboratory of Forensic Medicine Toxicology, Judicial Appraisal Center, Guizhou University of Traditional Chinese Medicine, Guiyang 550000, China
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HUANG ChunhuaHUANG Chunhua
Guizhou Provincial Key Laboratory of Forensic Medicine Toxicology, Judicial Appraisal Center, Guizhou University of Traditional Chinese Medicine, Guiyang 550000, China
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XIA MingXIA Ming
Guizhou Provincial Key Laboratory of Forensic Medicine Toxicology, Judicial Appraisal Center, Guizhou University of Traditional Chinese Medicine, Guiyang 550000, China
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LI MaojuanLI Maojuan
Guizhou Provincial Key Laboratory of Forensic Medicine Toxicology, Judicial Appraisal Center, Guizhou University of Traditional Chinese Medicine, Guiyang 550000, China
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WANG SiqiWANG Siqi
Guizhou Provincial Key Laboratory of Forensic Medicine Toxicology, Judicial Appraisal Center, Guizhou University of Traditional Chinese Medicine, Guiyang 550000, China
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LOU DidongLOU Didong
Guizhou Provincial Key Laboratory of Forensic Medicine Toxicology, Judicial Appraisal Center, Guizhou University of Traditional Chinese Medicine, Guiyang 550000, China
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Affiliation:Guizhou Provincial Key Laboratory of Forensic Medicine Toxicology, Judicial Appraisal Center, Guizhou University of Traditional Chinese Medicine, Guiyang 550000, China
Clc Number:R-33
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Abstract:

Kidneys filter bloodand regulate fluid and electrolyte balances. However, the kidney is susceptible to toxicity of various compounds, Resulting in renal damage. Hence, prevention and treatment of renal injury is a hot research topic. Zebrafish is an ideal animal model, because it is closely related to humans in terms of morphology, physiology, and kidney functions and its response to compounds. In this article, we review the method and evaluation indexes of zebrafish kidney injury modeling.

Key words:zebrafish; kidney injury; animal models

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Received:March 14,2023
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Online: January 22,2024
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