+Advanced Search
Home > Archive>Volume 34, Issue 1, 2024 >130-138. DOI:10. 3969 / j.issn.1671-7856. 2024. 01. 017
PDF HTML XML Export Cite reminder
Progress in irisin and its upstream and downstream antidepressants
Author:
Affiliation:

1. Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China. 2. School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine, Tianjin 301617. 3. School of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin 301617

Clc Number:

R-33

  • Article
    • | |
  • Metrics
    • |
  • Reference
    • |
  • Related
    • |
  • Cited by
    • | |
  • Comments
    Abstract:

    Depression is a major cause of disability and has adverse effects. Despite the many types of antidepressants, clinical treatments of depression remain poor. Therefore, novel anti-depressant mechanisms need to be explored. The beneficial effects of irisin on the nervous system are gradually being elucidated, and studies have found that irisin has an anti-depressant effect, which may become a new treatment for depression. This study explored the mechanism of irisin and its upstream and downstream anti-depressants by reviewing the existing studies explaining the link between irisin and depression, and proposes that SIRT1/ PGC-1α may mediate FNDC5/ irisin to regulate BDNF to promote neurogenesis and improve depression, which provides a new idea to study irisin and its upstream and downstream antidepressants.

    Reference
    Related
    Cited by
Get Citation

Copy
Share
Article Metrics
  • Abstract:414
  • PDF: 1320
  • HTML: 0
  • Cited by: 0
History
  • Received:March 27,2023
  • Online: March 04,2024
Article QR Code
You are the first3046587 Visitors
® 2025 All Rights Reserved
Address：5 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China Postcode： Phone：86-10-67779337 E-mail:bjb@cnilas.org
Supported by:Beijing E-Tiller Technology Development Co., Ltd.