Research progress on the role of SHP-2 in tumor-associated macrophages
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Affiliation:

1. Department of General Surgery, the First Hospital Affiliated to Hebei North University, Zhangjiakou 075000, China. 2. Cancer Research Institue, the First Hospital Affiliated to Hebei North University, Zhangjiakou 075000. 3. Hebei North University, Zhangjiakou 075000. 4. Nankai Clinical College Affiliated to Tianjin Medical University, Tianjin 300100

Clc Number:

R-33

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    Abstract:

    Tumor-associated macrophages (TAMs) are the predominant cell group in the tumor microenvironment(TME) and are the most important regulatory cells of immune system suppression and tumor cell proliferation in TIME. Src homology-2 domain-containing protein tyrosine phosphatase 2 (SHP-2) is a non-receptor protein tyrosine phosphatase that plays an important role in the transmission of signals from the cell surface to the nucleus. SHP-2 is a key intracellular regulatory factor mediating cell proliferation and differentiation and is involved in a variety of growth factor and cytokine signaling pathways linking the cell surface to the nucleus. Recent studies have shown that SHP-2 is a key enzyme in determining the function of TAMs, but because of its variable function, it plays different or even opposite roles in different solid TMEs. This paper reviews the function of SHP-2 in TAMs and related solid tumors to provide a comprehensive reference for tumor immunity and targeted therapy research.

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History
  • Received:May 09,2023
  • Online: March 04,2024
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