Objective Explore changes in polysaccharides in Jiangxiangru before and after ginger juice preparation, and evaluate polysaccharide anti-inflammatory and antioxidant activities before and after processing. Methods The contents of Jiangxiangru polysaccharide ( JXRPs ) and Ginger juice processed of Jiangxiangru polysaccharide ( JZJXRPs) before and after processing were determined by phenol-sulfuric acid method. We used the swelling model in rats and endotoxin ( LPS) to establish the RAW264. 7 mouse macrophage inflammation model. The optimal administration concentration was determined using a cell proliferation (MTT) assay. Enzyme-linked immunosorbent assay (ELISA) were used to measure Interleukin-6 ( IL-6 ) , Interleukin-12 ( IL-12 ) , Nitric oxide ( NO ) , Interleukin-4 ( IL-4 ) , and Interleukin-10 ( IL-10) . Bleeding time of mice by tail cutting was observed to evaluate the hemostatic effect. The ability to Remove 1,1-diphenyl-2-picryl-hydrazyl radical (DPPH) and 2,2’ -Azinobis-(3-ethylbenzthiazoline-6-sulphonate) (ABTS) was used to evaluate in vitro antioxidant activity. Results The contents of JXRPs and JZJXRPs were 13% and 22%,respectively. In swollen rats at 4 h after injection, compared with the model group, 200 mg / kg JXRPs and 100 mg / kg JZJXRPs significantly reduced rat swelling ( P<0. 05 ) . In vitro anti-inflammation assessment showed that the polysaccharides before and after processing significantly inhibited secretion of IL-6, IL-12, and NO ( P<0. 01 ) and promoted secretion of IL-4 and IL-10 ( P< 0. 01) , and also that processing post-effects were stronger. The hemostatic experiment show that, compared with the control group, JXRPs increased hemostasis, but without a significant difference,and no significant difference was found using JZJXRPs, although high doses showed a trend to increase hemostasis. In vitro antioxidant activity showed that JXRPs and JZJXRPs had different scavenging abilities for DPPH and ABTS with IC50 values of JXRPs of 0. 2215 and 0. 2110 mg / ml, respectively, and IC50 values of JZJXRPs of 0. 1651 and 0. 1884 mg / mL,respectively. Conclusions After Jiangxiangru is produced in ginger juice, it promotes dissolution of polysaccharides and increases polysaccharide content. Anti-inflammatory, hemostasis, and antioxidant capacities are stronger in JZJXRPS than JXRPS, which lays the foundation for follow-up research and clinical applications of JXRPS.