Research progress of non⁃coding RNA in methamphetamine⁃induced addiction and neurotoxicity
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Key Laboratory of Drug Dependence and Treatment, National Health Commission, School of Forensic Medicine, Kunming Medical University, Kunming 650500, China

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R-33

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    Abstract:

    Methamphetamine ( METH) is highly addictive and neurotoxic, which causes cognitive and memory dysfunction in abusers. The harm of METH lies not only in its own toxicity, but also in the high physical and mental dependence of drug addicts, often causing mental disorders and violent behavior, bringing great safety risks to society.Non-coding RNA ( ncRNA) does not encode proteins and is an important factor in regulating gene expression at the posttranscriptional level. Studies have shown that ncRNA plays an important regulatory role in methamphetamine-induced addiction and neurotoxicity, but the specific mechanism is unclear. This article reviews the current research progress of ncRNA in regulating METH-induced addiction and neurotoxicity to provide a reference for ncRNA as a forensic identification index and potential therapeutic target for METH abusers.

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History
  • Received:April 24,2023
  • Online: May 07,2024
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